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Biopsy with thermally-responsive untethered microtools.

Evin Gultepe1, Jatinder S Randhawa, Sachin Kadam

  • 1Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Advanced Materials (Deerfield Beach, Fla.)
|October 11, 2012
PubMed
Summary

Untethered microgrippers, activated by heat, can access confined bodily spaces for tissue removal. This study demonstrates their successful use for in vivo biopsy in a porcine bile duct.

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Area of Science:

  • Minimally invasive surgical techniques
  • Biomedical engineering
  • Gastrointestinal diagnostics

Background:

  • Traditional biopsy methods can be invasive and challenging in narrow anatomical locations.
  • The need for advanced tools to access and sample tissue from delicate internal structures is growing.
  • Untethered microdevices offer potential for navigating complex biological environments.

Purpose of the Study:

  • To demonstrate the feasibility of using thermally activated, untethered microgrippers for in vivo tissue biopsy.
  • To evaluate the microgrippers' capability to access and excise tissue from a narrow biological conduit.
  • To assess the potential of this technology for diagnostic analyses in internal organs.

Main Methods:

  • Development of thermally activated, untethered microgrippers.

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  • In vivo experimental setup using a porcine bile duct model.
  • Demonstration of microgripper navigation and tissue excision within the bile duct.

    • Main Results:

    • Successful navigation of untethered microgrippers into the narrow porcine bile duct.
    • Effective excision of tissue samples using the microgrippers for diagnostic purposes.
    • Feasibility of in vivo biopsy demonstrated in a relevant anatomical model.

    Conclusions:

    • Thermally activated, untethered microgrippers are a viable tool for minimally invasive in vivo biopsy.
    • This technology shows promise for tissue sampling in challenging anatomical locations like the bile duct.
    • Further research could expand the application of these microgrippers in internal diagnostics.