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Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation

Sara Ovejero1, Patricia Ayala, Avelino Bueno

  • 1Instituto de Biología Molecular y Celular del Cáncer and Departamento de Microbiología y Genética, Universidad de Salamanca/Consejo Superior de Investigaciones Científicas, 37007 Salamanca, Spain.

Molecular Biology of the Cell
|October 12, 2012
PubMed
Summary

Cdc14A dephosphorylates Wee1, preventing its degradation and counteracting Cdk1-cyclin B1 activity. This regulation is crucial for maintaining proper mitotic timing and cell cycle progression.

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