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Updated: May 17, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Interstitial lung disease in a patient with chronic granulomatous disease
Mozhgan Moghtaderi1, Sara Kashef, Nima Rezaei
1Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran ; Department of Pediatrics, Division of Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result from recurrent severe infections; however, vigorous inflammatory response could also cause respiratory diseases.
Case Presentation:
Herein, an 11 year-old patient with CGD is presented who suffered from chronic cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computed tomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.
Conclusion:
Early recognition of manifestations associated with CGD and appropriate treatment could prevent further complications and reduce morbidity and mortality in this group of patients.
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