Related Experiment Video
Updated: May 17, 2026
08:38
Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
Published on: September 1, 2011
Aripiprazole reverses paliperidone-induced hyperprolactinemia
Nieves Basterreche1, Mercedes Zumárraga, Aurora Arrue
1Short Stay Unit, Hospital de Zamudio, Red de Salud Mental de Bizkaia, 48170 Zamudio, Bizkaia, Spain. nieves.basterrecheizaguirre@osakidetza.net
Actas Espanolas De Psiquiatria
|October 19, 2012
Summary
Hyperprolactinemia, a side effect of antipsychotics, can be reversed. Adding aripiprazole to paliperidone treatment effectively resolved this issue in a patient, avoiding dose reduction or antipsychotic switching.
Area of Science:
- Psychiatry
- Endocrinology
- Pharmacology
Background:
- Hyperprolactinemia is a frequent adverse effect of antipsychotic medications.
- Current management strategies involve dose reduction or switching antipsychotics, risking patient decompensation.
Observation:
- A female patient experienced hyperprolactinemia during paliperidone treatment.
- The patient was treated with a combination of paliperidone and aripiprazole (5 mg/day).
Findings:
- Combined treatment with aripiprazole (5 mg/day) successfully reversed paliperidone-induced hyperprolactinemia.
- The normalization of prolactin levels occurred within four weeks of initiating combined therapy.
Implications:
- Aripiprazole augmentation may be a viable strategy for managing antipsychotic-induced hyperprolactinemia.
- This approach offers an alternative to dose reduction or antipsychotic switching, potentially preserving treatment efficacy.
Related Concept Videos
01:24Mania and Antimanic Drugs: Overview
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as a...
01:26Psychosis: Goals of Pharmacotherapy
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
01:08Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
01:28Psychosis and Antipsychotic Drugs: Overview
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
01:21Antipsychotic Drugs: Typical and Atypical Agents
Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
01:21Antipsychotic Drugs: Therapeutic Uses and Side Effects
Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...