Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Golgi Apparatus01:49

Golgi Apparatus

As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
Golgi Apparatus01:09

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
Golgi Matrix Proteins01:12

Golgi Matrix Proteins

Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycosyltransferases as Oncogenic Drivers: Lessons from Cancer Genome Mining.

DNA and cell biologyĀ·2026
Same author

Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers.

Proceedings of the National Academy of Sciences of the United States of AmericaĀ·2026
Same author

Siamese Twins: The Multimodular Mechanisms of Golgi Maturation and Glycan Synthesis Are Coupled at Their Core.

Sub-cellular biochemistryĀ·2026
Same author

HERPUD1 mediates palmitic acid-induced UPR sustaining TNBC aggressiveness and is destabilized by CK2 pharmacological inhibition.

Cell death & diseaseĀ·2025
Same author

Insights into the Functional Responses of Four Neotropical-Native Parasitoids to Enhance Their Role as Biocontrol Agents Against <i>Anastrepha fraterculus</i> Pest Populations.

InsectsĀ·2025
Same author

Egg Allocation on <i>Anastrepha ludens</i> Larvae by Mass-Reared <i>Diachasmimorpha longicaudata</i> Females.

InsectsĀ·2025
Same journal

The Power of Nup85: Controlling Molecular Traffic and Cellular Fate.

Traffic (Copenhagen, Denmark)Ā·2026
Same journal

Traffic Light Commentary-Src in the Upside Down: A Kinase Turned Inside Out.

Traffic (Copenhagen, Denmark)Ā·2026
Same journal

Integrating Lateral Super-Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways.

Traffic (Copenhagen, Denmark)Ā·2026
Same journal

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies.

Traffic (Copenhagen, Denmark)Ā·2026
Same journal

Mechanistic Insight Into Clathrin-Mediated Endocytosis in Plants.

Traffic (Copenhagen, Denmark)Ā·2026
Same journal

Clathrin-Mediated Endocytosis in Plants: Historical to Modern Advances.

Traffic (Copenhagen, Denmark)Ā·2026
See all related articles

Related Experiment Video

Updated: May 17, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

Signaling circuits on the Golgi complex.

Jorge Cancino1, Alberto Luini

  • 1Institute of Protein Biochemistry, National Research Council, Via Pietro, Castellino 111, 80131 Naples, Italy.

Traffic (Copenhagen, Denmark)
|October 20, 2012
PubMed
Summary
This summary is machine-generated.

Signaling proteins on the Golgi complex regulate cargo transport and cell signaling. Understanding these pathways is crucial for cell function and disease, though their coordination remains unclear.

More Related Videos

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

Related Experiment Videos

Last Updated: May 17, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
09:40

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum

Published on: September 20, 2011

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
10:13

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The Golgi complex is a key organelle involved in cellular signaling pathways.
  • Signaling proteins on the Golgi regulate cargo trafficking in anterograde and retrograde pathways.
  • These proteins impact Golgi structure, function, and the phosphorylation of transport machinery.

Purpose of the Study:

  • To investigate the roles of signaling proteins in Golgi-mediated cargo trafficking.
  • To explore the effects of these proteins on Golgi structure and function.
  • To elucidate the interplay between Golgi signaling pathways, secretion, and cellular functions.

Main Methods:

  • Focus on signaling proteins regulating anterograde and retrograde cargo transport.
  • Analysis of protein effects on Golgi structure and function.
  • Investigation of key component phosphorylation in the transport machinery.

Main Results:

  • Signaling pathways on the Golgi complex are central to cell signaling regulation.
  • The activation and coordination of these signaling molecules are not yet fully understood.
  • Describing pathway interplay with secretion is essential for understanding cellular machinery.

Conclusions:

  • The Golgi complex acts as a central hub for cell signaling regulation.
  • Further research is needed to understand the activation and coordination of Golgi-resident signaling molecules.
  • Understanding these pathways is vital for comprehending cellular functions and pathological conditions.