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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Methylome alterations "mark" new therapeutic opportunities in glioblastoma
Eric H Raabe1, Charles G Eberhart
1Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. eraabe2@jhmi.edu
Cancer Cell
|October 20, 2012
Abstract:
In this issue of Cancer Cell, Sturm et al. report that global DNA methylation patterns in glioblastoma multiforme divide adult and pediatric tumors into subgroups that have characteristic DNA mutations, mRNA profiles, and most importantly, different clinical behaviors. These findings suggest novel opportunities for therapeutics for this dreaded disease.
