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Updated: May 17, 2026
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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Immunotherapy for castration-resistant prostate cancer.
Guru Sonpavde1, Philip W Kantoff
1Department of Medicine, Section of Medical Oncology, University of Alabama at Birmingham (UAB) Comprehensive Cancer Center, Birmingham, AL 35294, USA.
The Urologic Clinics of North America
|October 23, 2012
Summary
Immunotherapy, including sipuleucel-T, shows promise for prostate cancer. Ongoing research explores novel approaches like T-lymphocyte checkpoint blockade and various vaccine platforms to improve patient outcomes.
Area of Science:
- Oncology
- Immunology
- Urology
Background:
- Sipuleucel-T, an autologous antigen-presenting cell therapy, has demonstrated improved survival in metastatic castration-resistant prostate cancer.
- Immunotherapy is increasingly recognized as a valid treatment strategy for prostate cancer.
- Numerous novel immunotherapeutic agents are under active investigation.
Purpose of the Study:
- To review emerging immunotherapeutic approaches for prostate cancer.
- To discuss the strengths and weaknesses of various immunotherapy platforms.
- To highlight the importance of developing predictive markers for immune response.
Main Methods:
- Review of current clinical trial data for immunotherapies in prostate cancer.
- Analysis of T-lymphocyte checkpoint blockade and poxvirus-based prime-boost strategies in Phase III trials.
- Examination of early-phase investigational platforms including radioimmunoconjugates, adenovirus-, DNA-, and Listeria-based therapies.
Main Results:
- Sipuleucel-T supports immunotherapy's role in metastatic castration-resistant prostate cancer.
- Several novel immunotherapies are in advanced stages of clinical evaluation.
- The development of predictive biomarkers is crucial for optimizing immunotherapy efficacy.
Conclusions:
- Immunotherapy represents a significant advancement in prostate cancer treatment.
- Diverse immunotherapeutic platforms offer potential for improved patient survival.
- Further research into predictive markers is essential for personalized immunotherapy strategies.
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