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Published on: May 11, 2015
[Pulmonary hypertension: from molecular pathophysiology to haemodynamic abnormalities]
S Duong-Quy1, S Rivière, Y Bei
1Service de physiologie, explorations fonctionnelles, hôpital Cochin, UPRES EA 2511, faculté de médecine, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75104 Paris, France. sy.duong-quy@cch.aphp.fr
Revue Des Maladies Respiratoires
|October 30, 2012
Summary
Pulmonary hypertension (PH) involves complex pulmonary haemodynamic disturbances and vascular remodeling. Understanding its molecular physiopathology is key to developing new therapies for this condition.
Area of Science:
- Cardiovascular Medicine
- Pulmonary Medicine
- Molecular Biology
Context:
- Pulmonary hypertension (PH) is a severe condition characterized by abnormal pulmonary haemodynamics.
- The disease involves structural changes and remodeling of pulmonary vessels, narrowing the vascular lumen.
- Pathophysiology is linked to imbalances in vasoconstrictors/vasodilators and cell proliferation/apoptosis.
Purpose:
- To review current knowledge on the molecular physiopathology of pulmonary hypertension.
- To highlight how understanding molecular mechanisms can advance PH therapeutics.
Summary:
- Pulmonary hypertension involves complex haemodynamic disturbances and vascular remodeling.
- Molecular imbalances in vasoconstrictors, vasodilators, cell proliferation, and apoptosis contribute to PH.
- This review synthesizes current understanding of PH molecular mechanisms.
Impact:
- Advances understanding of pulmonary hypertension pathophysiology.
- Provides insights into potential therapeutic targets for PH.
- Facilitates the development of novel treatments for pulmonary hypertension.
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