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Updated: May 17, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
[Prenatal diethylstilbestrol exposure and breast cancer]
S Frigo1, C Malina, C Mathelin
1Unité de sénologie, pôle de gynécologie-obstétrique, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France. severine.frigo@chru-strasbourg.fr
Abstract:
Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified. Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40 years. This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero. It details the risk of breast cancer for "DES daughters" and support possible screening modalities.
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