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hs-CRP and oxidative stress in young CAD patients: A pilot study
Suman B Sharma1, Seema Garg, Abhinav Veerwal
1Department of Biochemistry, University College of Medical Sciences & GTB Hospital, Delhi, India.
Insights
Young Indian men with premature coronary artery disease (CAD) exhibit significant oxidative stress, dyslipidemia, and elevated high sensitivity-C reactive protein (hs-CRP) levels. These factors combined increase the risk prediction for early-onset CAD in this population.
Area of Science:
- Cardiology
- Biochemistry
- Preventive Medicine
Background:
- Premature coronary artery disease (CAD) presents a significant health concern in India.
- Understanding the underlying risk factors in young individuals is crucial for early detection and intervention.
Purpose of the Study:
- To investigate the levels of oxidative stress markers, lipid profiles, and high sensitivity-C reactive protein (hs-CRP) in young male CAD patients.
- To assess the association of these markers with premature CAD in the Indian population.
Main Methods:
- The study included male CAD patients under 40 years and age/sex-matched healthy controls.
- Fasting blood samples were analyzed for lipid profiles, malondialdehyde (MDA), antioxidant enzymes (e.g., glutathione peroxidase), and hs-CRP.
Main Results:
- 90% of young CAD patients presented with dyslipidemia, characterized by elevated triglycerides, low HDL-cholesterol, and high LDL-cholesterol.
- Significantly increased serum MDA and hs-CRP levels (p<0.0001) were observed in CAD patients compared to controls.
- Reduced glutathione peroxidase activity (p<0.05) and high-risk hs-CRP levels were noted in all young CAD patients.
Conclusions:
- Elevated hs-CRP levels, dyslipidemia, and oxidative stress are significant contributors to the predictive value of premature CAD in young Indian men.
- These findings highlight the importance of assessing these biomarkers for early identification and management of CAD risk in younger populations.
Abstract:
Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.
