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Updated: May 17, 2026
08:15
Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
Published on: October 17, 2014
Cadherin junctions and their cytoskeleton(s).
William M Brieher1, Alpha S Yap
1Department of Cell and Developmental Biology, University of Illinois, Urbana, IL 61801, USA. wbrieher@illinois.edu
Current Opinion in Cell Biology
|November 7, 2012
Summary
Cadherins cooperate with diverse cytoskeletons. This review highlights actin filament dynamics, including Arp2/3
Area of Science:
- Cell biology
- Biochemistry
- Molecular biology
Background:
- Cadherins are crucial cell adhesion receptors.
- Their function is closely linked to the cytoskeleton.
- Previous research focused on actin-cadherin interactions.
Purpose of the Study:
- To review the diverse cytoskeletal networks influencing cadherin function.
- To highlight the roles of actin filament dynamics and microtubules.
Main Methods:
- Literature review of cadherin-cytoskeleton interactions.
- Focus on actin nucleation and microtubule effects.
Main Results:
- Actin filament dynamics, regulated by Arp2/3, are key at cadherin junctions.
- Microtubules also significantly impact cadherin function.
- Cadherins interact with multiple dynamic cytoskeletal networks.
Conclusions:
- Cadherin function relies on complex interactions with both actin and microtubules.
- Understanding these interactions is vital for cell adhesion research.
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