Related Experiment Video
Updated: May 16, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives
Aurelio Lorico1, Javier Mercapide, Germana Rappa
1Cancer Research Program, Roseman University of Health Sciences, 89104, Henderson, NV, USA, alorico@roseman.edu.
Abstract:
Innovative approaches to specifically target the melanoma subpopulation responsible for local invasion and metastatic dissemination are needed. Prominin-1 (CD133) expression has been observed in many melanoma cell lines, as well as in primary and metastatic melanomas from patients. Although its function(s) in melanoma is presently unknown, prominin-1 may represent a molecular target, due to its association with melanoma stem cells and with the metastatic phenotype.
Related Concept Videos
Mitogens and the Cell Cycle
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

