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Related Experiment Videos

Elevated serum IgE, eosinophilia, and lung function in rubber workers.

R Bascom1, M E Baser, R J Thomas

  • 1Department of Environmental Health Sciences, Johns Hopkins Medical Institutions, Baltimore, Maryland.

Archives of Environmental Health
|January 1, 1990
PubMed
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Workers in a synthetic rubber thermoinjection process showed signs of sensitization, with increased eosinophilia and immunoglobulin E (IgE) levels. However, no persistent respiratory health effects or lung function changes were detected after improved ventilation.

Area of Science:

  • Occupational Health
  • Environmental Medicine
  • Immunology

Background:

  • An outbreak of acute respiratory illness with eosinophilia occurred in rubber workers using a thermoinjection process.
  • The potential for persistent respiratory effects and allergic etiology required further investigation.

Purpose of the Study:

  • To assess persistent respiratory health effects in rubber workers exposed to the thermoinjection process.
  • To investigate the possible allergic basis of the observed respiratory syndrome.

Main Methods:

  • A survey was conducted 1 month post-ventilation improvement.
  • Methods included spirometry, diffusing capacity, serum IgE, total eosinophil count, and skin patch testing.
  • Both cross-shift and cross-week lung function tests were performed.

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Main Results:

  • No significant differences in baseline, cross-shift, or cross-week lung function were found between exposed and control groups.
  • A higher prevalence of eosinophilia or elevated serum IgE was observed in exposed workers (44%) compared to controls (11%).
  • These elevated markers were not associated with employment in the work area 9 months later.

Conclusions:

  • The thermoinjection process was linked to transient eosinophilia and elevated IgE, suggesting sensitization to rubber components.
  • No demonstrable long-term impact on pulmonary function was identified in this cohort.
  • Improved ventilation may have mitigated acute effects, but sensitization occurred.