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A basic set of homeostatic controller motifs
T Drengstig1, I W Jolma, X Y Ni
1Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway.
Biophysical Journal
|December 4, 2012
Summary
Living systems use adaptation and homeostasis to maintain stability. This study details two-component controller motifs, inflow and outflow control, explaining robust homeostatic mechanisms against environmental changes.
Area of Science:
- Systems Biology
- Biochemistry
- Physiology
Background:
- Homeostasis is crucial for life, yet reaction kinetic mechanisms for robust stability are poorly understood.
- Environmental perturbations challenge cellular homeostasis, necessitating effective regulatory strategies.
Purpose of the Study:
- To describe a complete set of two-component controller motifs for robust homeostasis.
- To elucidate the operational modes and integration capabilities of these motifs within cellular systems.
Main Methods:
- Analysis of reaction kinetic mechanisms.
- Identification and classification of two-component controller motifs.
- Physiological examples and pathway analysis.
Main Results:
- A complete set of two-component controller motifs (inflow and outflow control) for robust homeostasis was identified.
- These motifs can integrate uptake and metabolism, adapting to environmental changes.
- Examples include altered microbial fermentation products and hormonal control systems.
Conclusions:
- The described controller motifs provide a foundational understanding of robust homeostatic mechanisms.
- Inflow and outflow control principles explain cellular adaptation and the integration of metabolic pathways.
- These motifs offer insights into complex biological regulation, including hormonal systems.
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