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Dual-frequency tissue harmonic suppression using phase-coded pulse sequence: proof of concept using a phantom.

Che-Chou Shen1, Hui-Ting Wang

  • 1Department of Electrical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan. choushen@mail.ntust.edu.tw

Ultrasonics
|December 11, 2012
PubMed
Summary
This summary is machine-generated.

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A new phase-coded pulse sequence effectively suppresses tissue harmonic generation in dual-frequency (DF) harmonic imaging. This method improves contrast-to-tissue ratio (CTR) by reducing unwanted harmonic signals at both fundamental (f(0)) and second harmonic (2f(0)) frequencies.

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Acoustic Engineering

Background:

  • Tissue harmonic generation limits nonlinear detection of microbubble contrast agents.
  • Conventional harmonic suppression methods are incompatible with dual-frequency (DF) imaging.
  • DF imaging requires suppression of signals at both f(0) and 2f(0) to enhance contrast-to-tissue ratio (CTR).

Purpose of the Study:

  • To develop a novel phase-coded pulse sequence for effective DF tissue harmonic suppression.
  • To improve contrast-to-tissue ratio (CTR) in DF harmonic imaging.

Main Methods:

  • Utilized a three-pulse phase-coded sequence with equidistant transmit phases for echo summation and harmonic cancellation.
  • Employed specific phase manipulation for the f(0) transmit component to suppress the 2f(0) signal.

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  • Manipulated the 2f(0) transmit phase to achieve inter-modulation harmonic suppression at the f(0) frequency.

    • Main Results:

    • The proposed sequence effectively removed second-order and higher-order harmonic signals at both f(0) and 2f(0) frequencies.
    • Experimental measurements showed a reduction in tissue harmonic magnitude by approximately 20 dB.
    • Significant improvement in contrast-to-tissue ratio (CTR) was observed at both imaging frequencies.

    Conclusions:

    • The novel phase-coded sequence effectively suppresses tissue harmonic backgrounds in DF harmonic imaging.
    • This technique enhances contrast detection by mitigating harmonic interference at f(0) and 2f(0).
    • The method offers improved CTR, crucial for accurate microbubble contrast agent imaging.