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Updated: May 16, 2026
11:32
Determination of the Relative Cell Surface and Total Expression of Recombinant Ion Channels Using Flow Cytometry
Published on: September 28, 2016
Acid-sensing ion channels in pathological conditions
Xiang-Ping Chu1, Zhi-Gang Xiong
1Department of Basic Medical Science, School of Medicine, University of Missouri, Kansas City, MO, USA. chux@umkc.edu
Advances in Experimental Medicine and Biology
|December 11, 2012
Summary
Acid-sensing ion channels (ASICs) are crucial in neurological disorders. Their activity can be modulated in pathological conditions, offering new therapeutic targets for neuronal injury.
Area of Science:
- Neuroscience
- Channel Physiology
- Molecular Biology
Background:
- Acid-sensing ion channels (ASICs) are proton-gated cation channels found in neuronal systems.
- ASIC1a channels are implicated in neuronal injury in conditions like ischemia and multiple sclerosis.
- ASIC1a channels typically desensitize rapidly under acidosis, questioning their role in injury.
Purpose of the Study:
- To investigate the role of ASICs in neurological disorders.
- To understand how ASIC properties are modulated in pathological conditions.
- To explore ASICs as potential therapeutic targets for neuronal injury.
Main Methods:
- Review of recent studies on ASIC function and modulation.
- Analysis of ASIC behavior under normal versus pathological conditions.
- Investigation of signaling molecule and biochemical change effects on ASICs.
Main Results:
- ASIC properties are significantly modulated by pathological conditions.
- Modulation can lead to enhanced and prolonged ASIC activity.
- This prolonged activity promotes the pathological functions of ASICs.
Conclusions:
- ASICs, particularly ASIC1a, play a critical role in acidosis-mediated neuronal injury.
- Modulation of ASICs in disease states enhances their detrimental effects.
- Understanding ASIC modulation offers new strategies for treating neurological disorders.
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