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A diffuse reflectance spectral imaging system for tumor margin assessment using custom annular photodiode arrays
Sulochana Dhar1, Justin Y Lo, Gregory M Palmer
1Department of Electrical and Computer Engineering, Duke University, Research Drive, Durham, NC 27708, USA.
Biomedical Optics Express
|December 18, 2012
Summary
This study introduces a novel fiberless diffuse reflectance spectroscopy (DRS) imaging system for tumor margin assessment. The new system offers improved scalability and quantitative tissue analysis for cancer detection.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Cancer Diagnostics
Background:
- Diffuse reflectance spectroscopy (DRS) is crucial for distinguishing benign from cancerous tissues during tumor margin assessment.
- Current multipixel DRS tools, often fiber-based probes, face limitations in scalability.
Purpose of the Study:
- To develop and present a novel, fiberless multipixel DRS imaging system for enhanced tumor margin assessment.
- To overcome the scalability limitations of existing fiber-based DRS probes.
Main Methods:
- Designed a fiberless DRS probe utilizing direct detection by custom photodetectors in contact with tissue.
- Implemented a 4 × 4 array of annular silicon photodetectors and a constrained free-space light delivery tube.
- Achieved a 256 mm(2) imaging area with 4.5 mm spatial resolution.
Main Results:
- Demonstrated a novel fiberless DRS imaging system for tumor margin assessment.
- Achieved a signal-to-noise ratio of 35 dB to 45 dB for normal and malignant breast tissue-mimicking phantoms (λ = 470 nm to 600 nm).
Conclusions:
- The developed fiberless DRS system represents a significant advancement in tumor margin assessment technology.
- This approach offers improved scalability and quantitative analysis capabilities for cancer diagnostics.
