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[Studies on pyospermia in male infertility]
1Department of Urology, Tohoku University, School of Medicine, Sendai, Japan.
Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|February 1, 1990
Summary
Pyospermia, characterized by high white blood cells in semen, significantly reduces sperm motility. Elevated granulocyte elastase in seminal fluid is identified as a key factor inhibiting sperm function in affected men.
Area of Science:
- Reproductive biology
- Urology
- Andrology
Context:
- Pyospermia affects male fertility, characterized by elevated white blood cells (WBCs) in semen (≥10/hpf).
- Previous studies suggest a link between seminal inflammation and reduced sperm quality.
- Understanding the specific mechanisms behind pyospermia-induced infertility is crucial for effective treatment.
Purpose:
- To investigate the relationship between pyospermia and sperm motility.
- To identify potential causative factors for reduced sperm motility in pyospermic men.
- To evaluate the role of granulocyte elastase in seminal plasma as a contributor to impaired sperm function.
Summary:
- This study analyzed 72 infertile men diagnosed with pyospermia out of 670 participants.
- Sperm motile efficiency index (SMEI) was significantly lower in pyospermic men compared to controls (WBC <5/hpf).
- Chronic prostatitis is implicated as a cause, with elevated granulocyte elastase levels (mean 2859.6 µg/L vs. 131.6 µg/L) found in pyospermic individuals, directly correlating with reduced sperm motility.
Impact:
- Identifies granulocyte elastase as a potential key inhibitor of sperm motility in pyospermia.
- Provides insights into the pathophysiology of male infertility associated with pyospermia.
- Suggests potential therapeutic targets for improving sperm function in affected men.