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Radiosurgery of brain cavernomas--long-term results
1Na Homolce Hospital, Prague, Czech Republic. roman.liscak@homolka.cz
Progress in Neurological Surgery
|December 22, 2012
Summary
Radiosurgery for brain cavernomas significantly reduced rebleeding risk and improved epilepsy symptoms in a long-term study. Lesion size decreased in over half of patients, showing radiosurgery
Area of Science:
- Neurosurgery
- Radiation Oncology
Background:
- Cavernoma radiosurgery effectiveness is debated.
- Verification requires long-term follow-up and observation of reduced rebleeding risk.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of radiosurgery for brain cavernomas.
- To assess changes in rebleeding risk, lesion size, and clinical symptoms post-treatment.
Main Methods:
- Retrospective analysis of 112 patients with brain cavernomas treated between 1992-2000.
- Median marginal dose of 16 Gy.
- Follow-up of 84 months to assess rebleeding, lesion regression, and symptom improvement.
Main Results:
- Annual rebleeding risk decreased from 2% to 0.5% after a 2-year latent interval.
- Cavernoma size decreased in 53% of patients; epilepsy improved in 45% of cases.
- Temporary and permanent morbidity rates were 14.6% and 0.9%, respectively.
Conclusions:
- Radiosurgery can effectively reduce rebleeding risk and improve symptoms in brain cavernoma patients.
- Lower marginal doses may reduce treatment-related morbidity.
- Further research is needed on repeated radiosurgery for treatment failures.
