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Lipid A, the immunostimulatory principle of lipopolysaccharides?
H Loppnow1, I Dürrbaum, H Brade
1Forschungsinstitut Borstel, FRG.
Advances in Experimental Medicine and Biology
|January 1, 1990
Abstract:
Lipid A has been found to be an inducer of IL-1 with similar potency as LPS. Partial structures of lipid A or core oligosaccharides are less active or not active at all. We propose that lipid A is the structure responsible for induction of immunostimulatory or immunoregulatory properties of LPS.