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Chronic kidney disease is associated with increased coronary artery atherosclerosis as revealed by multidetector

Sion K Roy1, Albert Cespedes, Dong Li

  • 1Division of Cardiology, Department of Medicine, Los Angeles Biomedical Research Center at Harbor-UCLA Medical Center, Torrance, California 90502, USA.

Texas Heart Institute Journal
|January 11, 2013
PubMed

Insights

Mild and moderate chronic kidney disease (CKD) significantly increase coronary artery atherosclerosis. Multidetector computed tomographic angiography (MDCTA) revealed this link, identifying pre-dialysis CKD as an independent risk factor for cardiovascular events.

Area of Science:

  • Cardiology
  • Nephrology
  • Radiology

Background:

  • Chronic kidney disease (CKD) is a known independent risk factor for cardiovascular events.
  • The relationship between pre-dialysis CKD and coronary artery atherosclerosis requires further elucidation.

Purpose of the Study:

  • To investigate the association between pre-dialysis CKD and coronary artery atherosclerosis using multidetector computed tomographic angiography (MDCTA).

Main Methods:

  • Retrospective analysis of 549 patients undergoing MDCTA.
  • Patients categorized into normal GFR, mild CKD, and moderate CKD groups.
  • Statistical analysis including ANOVA, chi-squared test, and multiple linear regression to assess plaque scores (TPS, SIS, SSS) in relation to GFR.

Main Results:

  • Mild and moderate CKD groups showed significantly higher Total Plaque Scores (TPS) compared to normal GFR.
  • Segment Involvement Scores (SIS) and Segment Stenosis Scores (SSS) were also significantly elevated in mild and moderate CKD patients.
  • MDCTA demonstrated a clear association between reduced GFR and increased coronary artery atherosclerosis.

Conclusions:

  • Pre-dialysis mild and moderate CKD are independent risk factors for coronary artery atherosclerosis.
  • MDCTA is a valuable tool for assessing coronary artery disease in CKD patients.
  • Early identification and management of CKD may be crucial for cardiovascular risk reduction.

Keywords:
Atherosclerosis/etiologycardiovascular diseases/etiology/prevention & controldisease progressionkidney failure, chronic/complicationsretrospective studiesrisk factorstomography, x-ray computed

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