Giant inflammatory fibroid polyp

Inflammatory fibroid polyps are uncommon but well documented polypoid lesions occurring in gastrointestinal tract, most commonly in the stomach followed by ileum and rarely in the colon, duodenum or esophagus, especially in the sixth decade of life. The lesions are characterized by variable proliferation of fibroblasts and small vessels which may involve the whole thickness of the digestive wall, in an edematous connective tissue accompanying a marked inflammatory cell infiltrate which contains numerous eosinophils. We present the case of a 33 years old male patient with a solid, cylindrical-shaped 11/6.5/5 cm tumor arising from the inferior 1/3rd of the esophagus and eso-gastric region, projecting into the lumen of the stomach. The morphological features and the immunohistochemical profile were consistent with the diagnosis of IFP. This case has peculiar clinical and pathological particularities (sex and age of the patient, location and large dimensions of the lesion) that should be kept in mind when evaluating a mesenchymal tumor of the eso-gastric junction.