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Related Concept Videos

Transcription Initiation01:47

Transcription Initiation

Initiation is the first step of transcription in eukaryotes. Prokaryotic RNA Polymerase (RNAP) can bind to the template DNA and start transcribing. On the other hand, transcription in eukaryotes requires additional proteins, called transcription factors, to first bind to the promoter region in the DNA template. This binding helps recruit the specific RNAP that can assemble on the DNA and start transcription.
The promoters and enhancers and their accessory proteins allow tight regulation of...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...

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Related Experiment Video

Updated: May 14, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

TAF7: traffic controller in transcription initiation.

Anne Gegonne1, Ballachanda N Devaiah, Dinah S Singer

  • 1Experimental Immunology Branch, NCI, NIH, Bethesda, MD, USA.

Transcription
|January 24, 2013
PubMed
Summary
This summary is machine-generated.

Transcription factor TAF7 regulates key steps in gene activation and is essential for cell growth. This protein

Keywords:
T cellsTAF7differentiationproliferationtranscriptional regulation

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Last Updated: May 14, 2026

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Published on: December 29, 2021

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High-throughput Purification of Affinity-tagged Recombinant Proteins
07:44

High-throughput Purification of Affinity-tagged Recombinant Proteins

Published on: August 26, 2012

Area of Science:

  • Molecular Biology
  • Gene Regulation
  • Cellular Processes

Background:

  • The TFIID complex is crucial for initiating gene transcription.
  • TAF7 (TBP-associated factor 7) is a key component of TFIID.
  • Understanding TAF7's role is vital for comprehending transcription control.

Purpose of the Study:

  • To elucidate the specific functions of TAF7 in transcription.
  • To investigate TAF7's regulation of transcription factors.
  • To connect TAF7's transcriptional role to cell proliferation.

Main Methods:

  • Biochemical assays to study protein interactions.
  • Enzymatic activity assays for transcription factors.
  • Cell proliferation assays.

Main Results:

  • TAF7 modulates the enzymatic activities of transcription factors.
  • TAF7 influences RNA polymerase II progression during transcription initiation.
  • TAF7's functions in transcription are linked to its necessity for cell proliferation.

Conclusions:

  • TAF7 plays a central role in regulating the early stages of transcription.
  • TAF7's multifaceted roles in transcription initiation underscore its importance in cell proliferation.