Related Experiment Video
Updated: May 14, 2026
In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
Published on: June 6, 2025
In vivo comparison between laser-treated and grit blasted/acid etched titanium
Ljupcho Prodanov1, Edwin Lamers, Joop Wolke
1Department of Biomaterials, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
Objective:
Laser profiling of titanium has been of considerable interest in the field of oral implantology. However, very few pre-clinical and clinical studies have been performed with laser-treated implants, especially focusing on isotropic roughness topography. The aim of the study was to compare the cortical bone response of Ti-implants discs treated with pico-sec pulsed laser (LAS) and conventional grit-blasted/acid-etched (GAE) method.
Materials And Methods:
Prior to the in vivo experiment, in vitro cell viability testing of the LAS surface treatment was preformed. Then, 5 mm diameter Titanium (Ti) discs treated with LAS and GAE method were implanted in a pre-validated rabbit tibia cortical bone model and assessed with histology and histomorphometric measurements. In total, eight New Zealand White adult female rabbits were used.
Results:
The in vitro cell viability testing with osteoblast-like cells confirmed cytocompatibility of the LAS surface treatment. Further, the rabbit experiment demonstrated a bone-to-implant contact of 68% (±17) for the laser-treated discs and 49% (±21) for the GAE discs 8 weeks after the implantation, which was statistically not different.
Conclusion:
Laser surface treatment gives the same results to the grit-blasting/acid-etched method and thus is a valid alternative to conventional roughening for dental implant materials.
