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Updated: May 14, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Spider bite-induced erythema multiforme.

Selçuk Özyurt¹, Onur Er, Fatma Sule Afsar

¹Department of Dermatology, Izmir Atatürk Education and Research Hospital, Izmir, Turkey. ozyurtselcuk@yahoo.com

Cutaneous and Ocular Toxicology

|January 29, 2013

Summary

A rare case of erythema multiforme (EM) developed in a pregnant woman after a spider bite. This immune-mediated reaction presented as targetoid lesions, likely triggered by the bite, marking a unique clinical observation.

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Last Updated: May 14, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Dermatology
Toxicology

Background:

Erythema multiforme (EM) is an immune-mediated mucocutaneous eruption.
EM typically presents with characteristic targetoid lesions, often triggered by infections in predisposed individuals.

Observation:

A 30-year-old pregnant woman presented with a necrotic lesion post-spider bite.
Within 8 days, she developed a widespread erythematous, vesicular, and targetoid rash on her extremities.
No systemic medications were administered due to her 16-week pregnancy.

Findings:

Clinical and histopathological findings confirmed the diagnosis of Erythema Multiforme (EM).
The patient had no recent medication use or history of herpetic infections.
The EM lesions were attributed to an insect bite reaction, specifically a spider bite.

Implications:

This case represents the first reported instance of Erythema Multiforme (EM) induced by a spider bite.
Highlights the potential for arthropod bites to trigger immune-mediated mucocutaneous reactions.
Emphasizes the importance of considering diverse triggers for EM, even in pregnant patients where diagnostic options are limited.