Related Experiment Video
Updated: May 14, 2026
05:31
Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
Characteristic SD-OCT findings in preeclampsia.
Marco R Pastore1, Umberto De Benedetto, Marco Gagliardi
1Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Milan, Italy.
Summary
Spectral-domain optical coherence tomography reveals unique tent-shaped macular edema and retinal detachment in preeclampsia patients. This imaging technique is crucial for diagnosing this specific type of acute macular edema.
Area of Science:
- Ophthalmology
- Medical Imaging
- Obstetrics
Background:
- Preeclampsia is a serious pregnancy complication characterized by high blood pressure and potential organ damage.
- Acute macular edema can occur secondary to preeclampsia, affecting vision.
Observation:
- High-resolution spectral-domain optical coherence tomography (SD-OCT) was used to image a patient with acute macular edema due to preeclampsia.
- The SD-OCT revealed bilateral macular edema with a distinctive tent-shaped organization.
- Massive neurosensorial retinal detachment, subfoveal clear cystic lesions with hyperreflective dots, and retinal pigment epithelium irregularities were observed.
Findings:
- SD-OCT demonstrated a unique pattern of macular edema and retinal detachment in preeclampsia.
- Specific hyperreflective irregularities were noted within the retinal layers and at the retinal pigment epithelium.
- The imaging findings were critical for the diagnosis of this specific macular edema presentation.
Implications:
- Spectral-domain optical coherence tomography is a vital tool for diagnosing macular edema secondary to preeclampsia.
- Understanding these specific OCT patterns can improve diagnostic accuracy and patient management.
- This case highlights the utility of advanced imaging in obstetric and ophthalmologic complications.
Related Concept Videos
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:29Cardiovascular System Abnormal Findings I: Inspection and Palpation
In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Abnormal findings observed during an inspection
01:20Pathophysiology of Diabetes
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
01:25Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...