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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Updated: May 14, 2026

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice
07:07

Lung microRNA Profiling Across the Estrous Cycle in Ozone-exposed Mice

Published on: January 7, 2019

Web resources for microRNA research.

Ulf Schmitz1, Olaf Wolkenhauer

  • 1Department of Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany. ulf.schmitz@uni-rostock.de

Advances in Experimental Medicine and Biology
|February 5, 2013
PubMed
Summary
This summary is machine-generated.

Thousands of microRNAs (miRNAs) have been discovered, necessitating organized cataloging. This has led to the development of numerous miRNA web resources and applications for data retrieval and analysis.

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Published on: August 21, 2019

Area of Science:

  • Molecular Biology
  • Bioinformatics

Background:

  • Thousands of microRNAs (miRNAs) have been discovered across taxa over the past decade.
  • The increasing number of identified miRNA genes requires systematic cataloging and annotation.
  • This has driven the development of specialized miRNA web resources.

Purpose of the Study:

  • To provide an overview of existing miRNA web resources and their functionalities.
  • To classify miRNA web resources based on data type and processing methods.
  • To introduce valuable miRNA web applications and discuss data retrieval strategies.

Main Methods:

  • Review and categorization of existing miRNA web databases (repositories) and web applications.
  • Classification based on data types: sequence, annotation, targets, regulation, expression, functional mapping.
  • Identification of species-specific and phenotype-focused resources.

Main Results:

  • Over three dozen web-accessible miRNA resources currently exist.
  • These resources are categorized into sequence/annotation databases, target prediction/validation tools, regulation/expression databases, and functional mapping tools.
  • Various species-specific and phenotype-focused resources are available.

Conclusions:

  • MiRNA web resources are essential for managing and analyzing the vast amount of miRNA data.
  • Understanding the different types of resources and their applications aids in efficient data retrieval.
  • Awareness of data retrieval strategies and potential pitfalls is crucial for researchers.