Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Scale-Up Processes01:14

Scale-Up Processes

The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanofusion-derived cathode composite microstructures with scalable mixed conducting matrix coatings for solid state batteries.

Nature communications·2026
Same author

Process characterisation of continuous ring layer wet granulation at small scale.

International journal of pharmaceutics: X·2025
Same author

Modeling of physical-mechanical and microbiological properties of tablets made of complex fluidized bed granules containing living yeast cells using common mixing rules.

International journal of pharmaceutics: X·2025
Same author

Modeling the influence of the microbial loading level of fluidized bed granules on physical-mechanical and microbiological tablet properties.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Tailoring Composite Microstructure Through Milling for Dry-Processed Sulfide-Based Solid-State Battery Cathodes.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Exploring the influence of the nanoporous structure of nickel-based superalloy membranes on emulsification performance.

International journal of pharmaceutics: X·2025
Same journal

Fluorescent merocyanines: from fundamental properties to applications as molecular probes, in bioimaging and as emissive dye aggregates.

Chemical Society reviews·2026
Same journal

Direct impure water electrolysis at industrial scale.

Chemical Society reviews·2026
Same journal

Catalytic valorization of polyolefins: from catalysts and processes to reactors.

Chemical Society reviews·2026
Same journal

Designing stable π-radicals.

Chemical Society reviews·2026
Same journal

Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.

Chemical Society reviews·2026
Same journal

Selective carbon-carbon bond cleavage involving alkene moieties.

Chemical Society reviews·2026
See all related articles

Related Experiment Video

Updated: May 14, 2026

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

Process engineering with planetary ball mills.

Christine Friederike Burmeister1, Arno Kwade

  • 1Technische Universität Braunschweig, Institute for Particle Technology, Volkmaroder Straße 5, 38104 Braunschweig, Germany. c.burmeister@tu-braunschweig.de a.kwade@tu-braunschweig.de.

Chemical Society Reviews
|February 8, 2013
PubMed
Summary
This summary is machine-generated.

Planetary ball mills are versatile for particle size reduction and mechanochemistry. Optimizing milling conditions, like ball properties and speed, is crucial for effective refinement, yield, and reduced contamination.

More Related Videos

Processing of Bulk Nanocrystalline Metals at the US Army Research Laboratory
08:58

Processing of Bulk Nanocrystalline Metals at the US Army Research Laboratory

Published on: March 7, 2018

Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

Related Experiment Videos

Last Updated: May 14, 2026

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments
13:05

Reliable Mechanochemistry: Protocols for Reproducible Outcomes of Neat and Liquid Assisted Ball-mill Grinding Experiments

Published on: January 23, 2018

Processing of Bulk Nanocrystalline Metals at the US Army Research Laboratory
08:58

Processing of Bulk Nanocrystalline Metals at the US Army Research Laboratory

Published on: March 7, 2018

Preparation and Reactivity of Gasless Nanostructured Energetic Materials
09:50

Preparation and Reactivity of Gasless Nanostructured Energetic Materials

Published on: April 2, 2015

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Mechanical Engineering

Background:

  • Planetary ball mills are established for particle size reduction.
  • Recent applications extend to mechanochemical synthesis.
  • Process complexity necessitates system-specific optimization.

Purpose of the Study:

  • To review key parameters influencing planetary ball mill processes.
  • To provide guidelines for modeling refinement, yield, and wear.
  • To explore energy transfer and motion patterns through simulation and experimentation.

Main Methods:

  • Review of parameters: grinding ball properties, filling ratio, revolution speed.
  • Application of discrete-element-method (DEM) for numerical simulations.
  • Correlation of simulations with experimental data and video recordings.

Main Results:

  • DEM simulations quantify energy transfer and its dependence on mill geometry.
  • Insights into motion patterns within the mill are provided.
  • Guidelines for optimizing milling conditions are illustrated.

Conclusions:

  • Understanding and modeling planetary ball mill processes are vital for effective mechanochemical applications.
  • DEM simulations offer valuable insights into energy dynamics and motion.
  • Optimized conditions enhance synthesis yield and minimize contamination.