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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Necrosis01:16

Necrosis

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Morphological Manifestations of Necrosis
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Inflammatory Bowel Disease I: Ulcerative Colitis

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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
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Inflammatory Bowel Disease II: Crohn's Disease

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Updated: May 14, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Necrotizing enterocolitis in term infants.

Robert D Christensen1, Diane K Lambert, Vickie L Baer

  • 1The Women and Newborns Program, Intermountain Healthcare, Salt Lake City, Ogden, UT 84111, USA. Robert.christensen@imail.org

Clinics in Perinatology
|February 19, 2013
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) in term neonates often arises as a treatment complication in neonatal intensive care units. Identifying at-risk infants and implementing human milk feeding programs may reduce NEC incidence.

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Last Updated: May 14, 2026

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Area of Science:

  • Neonatology
  • Pediatric Gastroenterology
  • Critical Care Medicine

Background:

  • Necrotizing enterocolitis (NEC) is a serious gastrointestinal condition affecting newborns.
  • While commonly seen in premature infants, NEC also occurs in term neonates, often as a secondary diagnosis.

Purpose of the Study:

  • To provide an overview of NEC in term neonates.
  • To analyze 52 cases of NEC in term infants admitted to a neonatal intensive care unit (NICU) over 11 years.

Main Methods:

  • Retrospective review of 52 term neonates diagnosed with NEC.
  • Analysis of patient data from Intermountain Healthcare.

Main Results:

  • All 52 cases of NEC occurred in neonates already admitted to the NICU for other conditions.
  • NEC was consistently a complication of treatment rather than a primary diagnosis.

Conclusions:

  • NEC in term neonates within the NICU setting is often iatrogenic.
  • Identifying high-risk NICU patients and utilizing appropriate human milk feeding volumes may decrease the incidence of term NEC.