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Published on: February 15, 2022
Acute bilateral angle closure glaucoma induced by methazolamide.
Ahmad A Aref1, Fouad E Sayyad, Bernadete Ayres
1Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL ; Illinois Eye and Ear Infirmary, University of Illinois at Chicago School of Medicine, Chicago, IL, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|February 23, 2013
Summary
Methazolamide can cause acute myopia and angle closure glaucoma. Stopping the medication resolves these vision problems, as confirmed by eye imaging.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma.
- Normal tension glaucoma requires ongoing management.
Observation:
- A 70-year-old male developed acute bilateral myopia and angle closure glaucoma after taking methazolamide.
- Clinical examination revealed shallow anterior chambers, ciliary body edema, and supraciliary effusions.
Findings:
- High-frequency ultrasonography and slit-lamp photography confirmed ciliary body edema, supraciliary effusions, and shallow posterior choroidal effusions.
- These ocular changes resolved after discontinuing methazolamide.
Implications:
- Methazolamide may induce secondary myopia and angle closure glaucoma.
- Discontinuation of methazolamide is an effective treatment for this adverse reaction.
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