[Fatal hepatitis caused by disulfiram]

A case of fatal fulminant hepatitis following treatment with disulphiram in a man aged 34 year is reported. Acute toxic hepatitis produced by disulphiram is a rare but serious side effect with a lethality about 40%. In the case reported here, immediate withdrawal of disulphiram administration on the earliest signs of hepatitis did not prevent toxic development of severe hepatic necrosis.