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Updated: May 13, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Comparison between unsintered hydroxyapatite/poly-L-lactic acid mesh and titanium mesh in bone regeneration of rabbit
Akinori Moroi1, Koichiro Ueki, Katsuhiko Okabe
1Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
Purpose:
The purpose of this study was to compare the bone regenerative capability of using unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) mesh and titanium mesh.
Materials And Methods:
Adult male white rabbits (n = 24) were divided into 2 groups. After incising along the mandible, 3 × 5 mm bone defects were made in both sides and covered by an uHA/PLLA mesh (n = 12) or a titanium mesh (n = 12) on the right side but no mesh on the left side (n = 12). The rabbits were sacrificed at 1, 2, and 4 weeks postoperatively, and formalin-fixed specimens were embedded in acrylic resin. The specimens were stained with hematoxylin and eosin. For immunohistochemical analysis, the specimens were treated with BMP-2.
Results:
The titanium group and uHA/PLLA group were significantly larger than the control group regarding the bone area ratio postoperatively at 2 and 4 weeks. However, there were no significant differences between the uHA/PLLA group and titanium group regarding the BMP-2.
Conclusions:
This study suggested that the uHA/PLLA mesh could increase new bone formation more than the absence of a mesh in bone defects. However, there was no significant difference between uHA/PLLA mesh and the titanium mesh in bone augmentation.
