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Related Experiment Video

Updated: May 13, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
12:22

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

Published on: August 4, 2018

Multimodal adaptive optics retinal imager: design and performance.

Daniel X Hammer1, R Daniel Ferguson, Mircea Mujat

  • 1Physical Sciences Inc., 20 New England Business Center, Andover, Massachusetts 01810, USA. dxhammer@gmail.com

Journal of the Optical Society of America. A, Optics, Image Science, and Vision
|March 5, 2013
PubMed
Summary

We developed a multimodal adaptive optics system (MAOS) integrating OCT and SLO imaging for high-resolution retinal disease detection and monitoring in humans and animals.

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Optical Imaging

Background:

  • Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO) are key for retinal disease detection.
  • Adaptive optics (AO) corrects ocular aberrations for improved imaging.
  • Combining these technologies offers comprehensive retinal visualization.

Purpose of the Study:

  • To develop a multimodal adaptive optics system (MAOS) for integrated OCT and SLO imaging.
  • To enable high-resolution, multifunctional retinal imaging in research and clinical settings.
  • To facilitate simultaneous SLO/OCT output with high-fidelity AO correction for diverse applications.

Main Methods:

  • Integrated OCT and SLO imaging channels into an AO beam path.
  • Designed optics and hardware for simultaneous SLO/OCT output and AO correction.
  • Tested the MAOS system on human subjects and rodents for performance characterization.

Main Results:

  • Demonstrated a novel MAOS integrating AO-corrected OCT and SLO.
  • Achieved high-resolution imaging capabilities for both human and animal retinas.
  • Validated the system's design for efficient location and orientation of retinal regions.

Conclusions:

  • The MAOS provides a powerful tool for advanced retinal imaging.
  • This system supports detection, monitoring, and therapeutic assessment of retinal diseases.
  • MAOS is suitable for human, primate, and small animal studies.