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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Hardy-Weinberg Principle

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.

Radiation Pressure: Problem Solving

Radiation Pressure: Problem Solving

The radiation pressure applied by an electromagnetic wave on a perfectly absorbing surface equals the energy density of the wave. The wave's momentum also gets transferred to the surface when an electromagnetic wave is entirely absorbed by it. The rate at which momentum is transmitted to an absorbing surface perpendicular to the propagation direction equals the force on the surface.
The average value of the rate of momentum transfer divided by the absorbing area represents the average force per...

Prokaryotic Transcriptional Activators and Repressors

Prokaryotic Transcriptional Activators and Repressors

The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...

Prokaryotic Transcriptional Activators and Repressors

Prokaryotic Transcriptional Activators and Repressors

The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...

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Related Experiment Video

Updated: May 13, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

Published on: September 13, 2013

New mandates? No problem for The Rockefeller University Press.

The Journal of Experimental Medicine

|March 12, 2013

Summary

This summary is machine-generated.

Our journals comply with new public access policies, including terms for text and data mining. We permit unrestricted reuse of published content for all entities, including commercial ones.

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Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors

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Cell Culture Techniques and Practices to Avoid Contamination by Fungi and Bacteria in the Research Cell Culture Laboratory

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Published on: April 29, 2010

Area of Science:

Biomedical research publishing
Scientific communication standards
Open access initiatives

Background:

New public access policies from Research Councils UK (RCUK) and the Wellcome Trust mandate content reuse terms.
Existing policies for The Journal of Cell Biology, The Journal of Experimental Medicine, and The Journal of General Physiology are compliant.
Specific licensing terms for third-party reuse, particularly for text and data mining, are a focus.

Discussion:

The necessity of specific licensing terms for reuse is questioned.
The journals' existing public access policy is fully compliant with RCUK and Wellcome Trust mandates.
A statement has been added to clarify permitted reuse of published text and data.

Key Insights:

Journals' public access policies align with funder mandates.
Unrestricted text and data mining is now explicitly permitted for all users.
This facilitates broader scientific reuse and secondary analysis of published research.

Outlook:

Encouraging wider data accessibility and computational analysis of scientific literature.
Potential for increased interdisciplinary research through open data sharing.
Setting a precedent for flexible content reuse in scientific publishing.