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Updated: May 13, 2026
26:48
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
Atypical subacute sclerosing panencephalitis with short onset latency
Kumar Saurabh1, Ratan Gupta, Shashi Khare
1Department of Pediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Indian Pediatrics
|March 12, 2013
Summary
Subacute sclerosing panencephalitis (SSPE) is a rare complication of measles in infants, presenting with seizures and altered sensorium. Early diagnosis via EEG and CSF analysis is crucial for management.
Area of Science:
- Neurology
- Pediatrics
- Infectious Diseases
Background:
- Subacute sclerosing panencephalitis (SSPE) is a rare, progressive neurological disorder.
- Measles infection is a known precursor to SSPE, particularly in unvaccinated populations.
- Infantile encephalopathy requires a broad differential diagnosis.
Observation:
- An 11-month-old infant presented with focal seizures, myoclonic jerks, and altered sensorium.
- The infant had a history of measles infection at eight months of age.
- Clinical presentation suggested an acute encephalopathy.
Findings:
- Electroencephalogram (EEG) revealed characteristic changes indicative of SSPE.
- Cerebrospinal fluid (CSF) analysis confirmed the presence of anti-measles antibodies.
- Diagnosis of SSPE was established based on clinical, EEG, and serological findings.
Implications:
- SSPE diagnosis requires consideration in infants with acute encephalopathy and a history of measles.
- Early identification of SSPE is vital for timely intervention and management.
- Understanding SSPE's link to measles emphasizes the importance of vaccination programs.
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