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Updated: May 13, 2026

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
Published on: December 20, 2017
Short cell-penetrating peptides: a model of interactions with gene promoter sites
V Kh Khavinson1, S I Tarnovskaya, N S Linkova
1I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Abstract:
Analysis of the main parameters of molecular mechanics (number of hydrogen bonds, hydrophobic and electrostatic interactions, DNA-peptide complex minimization energy) provided the data to validate the previously proposed qualitative models of peptide-DNA interactions and to evaluate their quantitative characteristics. Based on these estimations, a three-dimensional model of Lys-Glu and Ala-Glu-Asp-Gly peptide interactions with DNA sites (GCAG and ATTTC) located in the promoter zones of genes encoding CD5, IL-2, MMP2, and Tram1 signal molecules.
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