Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the timing and level of...
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin dynamics and cellular energy homeostasis.

Journal of biochemistry·2026
Same author

Context-dependent interplay of Swi-Snf and Tup1-Cyc8 influences chromatin and transcription at antagonistically regulated genes.

Nature communications·2026
Same author

Author Correction: The SESAME complex regulates cell senescence through the generation of acetyl-CoA.

Nature metabolism·2026
Same author

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex.

bioRxiv : the preprint server for biology·2026
Same author

Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome.

bioRxiv : the preprint server for biology·2026
Same author

Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.

NAR molecular medicine·2026
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells
13:20

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells

Published on: July 29, 2010

Chromatin and signaling.

Tamaki Suganuma1, Jerry L Workman

  • 1Stowers Institute for Medical Research, United States. tas@stowers.org

Current Opinion in Cell Biology
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Cell signaling pathways coordinate molecules to regulate cell functions and gene activation. Emerging research reveals chromatin receives signals, advancing understanding of development and disease.

More Related Videos

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines

Published on: June 17, 2017

Related Experiment Videos

Last Updated: May 13, 2026

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells
13:20

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells

Published on: July 29, 2010

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines
11:39

Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines

Published on: June 17, 2017

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Epigenetics

Background:

  • Cellular signaling pathways are crucial for survival, development, and homeostasis.
  • These pathways involve interactions between stimuli, receptors, and enzymes.
  • Signaling molecules often interact with transcriptional machinery and chromatin.

Purpose of the Study:

  • To explore the intricate relationship between cell signaling and chromatin.
  • To understand how signaling pathways regulate gene expression.
  • To investigate the emerging role of chromatin in receiving cellular signals.

Main Methods:

  • Analysis of molecular interactions within signaling pathways.
  • Investigation of transcriptional regulation by signaling molecules.
  • Examination of chromatin modifications in response to cellular signals.

Main Results:

  • Signaling pathways directly influence gene activation via transcription machinery and histone modifications.
  • Evidence suggests chromatin itself acts as a recipient of cellular signals.
  • Novel regulatory mechanisms involving chromatin and signaling are being uncovered.

Conclusions:

  • Cellular signaling profoundly impacts chromatin biology.
  • Chromatin's role in receiving signals opens new avenues for research.
  • Understanding these mechanisms is vital for advancing knowledge in development and disease.