Non-specific decrease of cell-mediated immunity in female mice during syngeneic and allogeneic pregnancy

Cell-mediated immunity is non-specifically reduced in the second half of H-2 incompatible pregnancy compared with syngeneic mating. Significant difference between syngeneic and allogeneic mated female mice was obtained using two independent tests: contact sensitivity to oxazolone (P smaller than 0.001) and local graft-versus-host reaction (P smaller than 0.01).