A systems-based computational model of alcohol's toxic effects on brain development

Julia M Gohlke1, Susanne Hiller-Sturmhöfel, Elaine M Faustman

  • 1Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

Summary

Fetal alcohol exposure disrupts neurodevelopment, impacting nerve cell generation and connections. Computational models show impaired neurogenesis causes more adult neuron loss than increased cell death during synaptogenesis.