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Updated: May 12, 2026
09:34
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Peptide self-assembly driven by oxo-ester mediated native chemical ligation
Dnyaneshwar B Rasale1, Indrajit Maity, Maruthi Konda
1Department of Chemistry, Indian Institute of Technology Indore, India.
Chemical Communications (Cambridge, England)
|April 19, 2013
Summary
Researchers utilized oxo-ester mediated native chemical ligation to create peptide self-assembly, forming supramolecular nanofibers and self-supporting gels for advanced biomaterials.
Area of Science:
- Biochemistry
- Materials Science
- Supramolecular Chemistry
Background:
- Native chemical ligation (NCL) is a powerful tool for peptide synthesis.
- Controlling peptide self-assembly is crucial for developing novel biomaterials.
Purpose of the Study:
- To explore oxo-ester mediated NCL for peptide self-assembly.
- To fabricate supramolecular nanofibers and self-supporting gels.
Main Methods:
- Utilized oxo-ester mediated native chemical ligation (NCL).
- Investigated peptide self-assembly triggered by NCL.
Main Results:
- Successfully generated peptide self-assembly.
- Fabricated supramolecular nanofibers.
- Created self-supporting gels.
Conclusions:
- Oxo-ester mediated NCL is effective for directing peptide self-assembly.
- This method offers a novel route to biomaterials like nanofibers and gels.
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