Related Experiment Videos
[Interlaboratory serum copper-zinc comparisons. Analytical performance during the first year].
F Baruthio1, F Pierre, J Arnaud
1Laboratoire de Biochimie et Toxicologie Epidémiologiques, INRS, Vandoeuvre.
Annales De Biologie Clinique
|January 1, 1990
Summary
Interlaboratory comparison programs for serum copper and zinc improved analytical performance. Participants showed enhanced accuracy and reproducibility in trace element determination after one year.
Area of Science:
- Clinical Chemistry
- Analytical Chemistry
- Trace Element Analysis
Context:
- The Trace Elements Commission of the French Society for Clinical Biology initiated an interlaboratory comparison program in 1988.
- This program focused on the determination of copper and zinc in serum samples.
Purpose:
- To enable participating laboratories to maintain and improve the accuracy of their analytical performance.
- To assess performance based on comparison with mean values, accuracy of additions, and between-run reproducibility.
Summary:
- After one year, significant improvements in homogeneity were observed, particularly for copper.
- Coefficients of variation for copper decreased from 30% to 21%, and for zinc from 29% to 15%.
- Participant performance was evaluated using individual and global scores, with accuracy yielding the best results.
Impact:
- Demonstrated a regular improvement in analytical performance among participating laboratories.
- Highlighted the effectiveness of interlaboratory comparisons in enhancing trace element determination accuracy.
- Provided a benchmark for global performance compared to international programs.