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Updated: May 11, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Short and long term mortality rates after a lower limb amputation.

L V Fortington1, J H B Geertzen, J J van Netten

  • 1Department of Rehabilitation Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands. l.v.fortington@umcg.nl

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
|May 1, 2013
PubMed
Summary

Mortality after lower limb amputation is high, with 22% dying within 30 days and 44% within 1 year. Cerebrovascular disease increases early death risk, while renal disease elevates long-term mortality risk.

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Area of Science:

  • Medical research
  • Clinical epidemiology
  • Surgical outcomes

Background:

  • Lower limb amputation is a significant intervention with potential for high mortality.
  • Understanding post-amputation mortality rates is crucial for patient care and resource allocation.

Purpose of the Study:

  • To determine mortality rates following a first lower limb amputation.
  • To identify subpopulations with increased mortality risk after amputation.

Main Methods:

  • Retrospective cohort study of 299 patients undergoing first transtibial or higher amputation.
  • Kaplan-Meier curves and Log Rank tests for survival analysis.
  • Logistic regression to assess odds of death at 30 days, 1 year, and 5 years.

Main Results:

  • Overall 30-day mortality was 22%, 1-year mortality was 44%, and 5-year mortality was 77%.
  • Patients with cerebrovascular disease had 2.3 times higher odds of 30-day death.
  • Patients with renal disease had 3.5 times higher odds of 1-year death and 5.4 times higher odds of 5-year death.
  • Age group 75-84 years showed better short-term outcomes compared to younger and older individuals.

Conclusions:

  • High mortality rates underscore the frailty of the lower limb amputation population.
  • Cerebrovascular disease is a significant risk factor for early mortality post-amputation.
  • Renal disease is a critical predictor of both short-term and long-term mortality after lower limb amputation.