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Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Folding

Protein Folding

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Related Experiment Video

Updated: May 11, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

The tripartite motif: structure and function.

Lucia Micale¹, Evelyne Chaignat, Carmela Fusco

¹Laboratory of Medical Genetics, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Advances in Experimental Medicine and Biology

|May 1, 2013

Summary

This summary is machine-generated.

The study details the structure and function of TRIM/RBCC proteins, crucial for cell cycle regulation and apoptosis. It elucidates the conserved tripartite motif and variable C-terminal domains, offering insights into their biochemical roles.

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Last Updated: May 11, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners

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Published on: June 30, 2013

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay

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Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues

Published on: July 14, 2015

Area of Science:

Molecular Biology
Cell Biology
Protein Structure

Background:

TRIM/RBCC proteins are a diverse family involved in critical cellular processes like apoptosis and cell cycle regulation.
These proteins share a conserved tripartite motif (RING, B-box, coiled-coil) and a variable C-terminal region.
The conserved architecture suggests underlying common biochemical functions across the TRIM/RBCC family.

Purpose of the Study:

To present the detailed structure of TRIM/RBCC proteins.
To propose the function of individual TRIM domains, including the C-terminal domain.
To elucidate the conserved biochemical mechanisms of TRIM/RBCC proteins.

Main Methods:

Structural analysis of TRIM/RBCC proteins.
Functional domain analysis.
Comparative evolutionary analysis of protein architecture.

Main Results:

Detailed structural presentation of the TRIM/RBCC protein family.
Proposed functional roles for each domain within the tripartite motif.
Characterization of the highly variable C-terminal domain's function.

Conclusions:

The conserved tripartite motif is key to the diverse cellular roles of TRIM/RBCC proteins.
Understanding individual domain functions provides insight into TRIM protein mechanisms.
This study enhances the comprehension of TRIM/RBCC protein family's biochemical functions and evolutionary significance.