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Updated: May 11, 2026
07:23
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
Published on: June 15, 2016
TRIM involvement in transcriptional regulation
Florence Cammas1, Konstantin Khetchoumian, Pierre Chambon
1Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP/Collège de France, Illkirch, France. florence.cammas@igbmc.fr
Advances in Experimental Medicine and Biology
|May 1, 2013
Summary
Tripartite motif (TRIM) proteins regulate gene expression by interacting with transcription factors. This chapter explores the molecular mechanisms behind TRIM protein regulation of transcription.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Tripartite motif (TRIM) proteins are crucial in multicellular eukaryotes.
- They participate in diverse cellular functions including cell cycle, differentiation, development, oncogenesis, and viral responses.
- Specific TRIM proteins, such as TIF1, PML, and RFP, are known to modulate gene expression.
Purpose of the Study:
- To examine the molecular interactions of key TRIM proteins.
- To elucidate the mechanisms by which TRIM proteins regulate transcription.
- To provide a comprehensive overview of TRIM-mediated transcriptional control.
Main Methods:
- Review of existing literature on TRIM protein functions.
- Analysis of molecular interaction data for TRIM proteins.
- Examination of studies detailing TRIM protein regulation of transcription factors.
Main Results:
- TRIM proteins interact with various sequence-specific transcription factors.
- These interactions lead to the modulation of transcriptional activity.
- Specific examples include TIF1, PML, and RFP, highlighting diverse regulatory roles.
Conclusions:
- TRIM proteins play a significant role in regulating gene expression.
- Understanding TRIM protein interactions is key to deciphering transcriptional control mechanisms.
- Further research into TRIM protein mechanisms can offer insights into cellular processes and disease.
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