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Leveraging material properties in fluorescence anion sensor arrays: a general approach
Pavel Anzenbacher1, Yuanli Liu, Manuel A Palacios
1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, OH 43403, USA. pavel@bgsu.edu
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 15, 2013
Summary
This study developed a novel sensor using a fluorescent calix[4]pyrrole probe embedded in poly(ether-urethane) hydrogels. The sensor array accurately identifies various anions, urine samples, and drugs, demonstrating the polymer environment
Area of Science:
- * Materials Science: Development of novel poly(ether-urethane) hydrogel copolymers for sensor applications.
- * Analytical Chemistry: Creation of a versatile fluorescent probe for detecting multiple analytes.
- * Polymer Chemistry: Synthesis and characterization of hydrogel matrices with tunable properties.
Background:
- * Increasing demand for sophisticated probes in sensor development.
- * Importance of leveraging known receptors for creating new sensing technologies.
- * Challenges in developing chemosensors for recognizing aqueous anions.
Purpose of the Study:
- * To guide the development of sensors from known receptors using a two-prong approach.
- * To convert a calix[4]pyrrole receptor into a fluorescent probe for ratiometric signaling.
- * To fabricate sensor arrays using poly(ether-urethane) hydrogels for electrolyte absorption and transport.
Main Methods:
- * Conversion of calix[4]pyrrole into a fluorescent probe for ratiometric signal generation.
- * Fabrication of sensor arrays using ten different poly(ether-urethane) hydrogel matrices with varying comonomer proportions.
- * Doping the hydrogels with a single probe and exposing them to various anions, urine samples, and non-steroidal anti-inflammatory drugs (NSAIDs).
Main Results:
- * A single fluorescent probe in ten different polyurethanes achieved 100% classification accuracy for eight anions and eight urine samples.
- * The polymer matrix significantly influenced the probe's recognition and self-assembly processes.
- * Demonstrated quantitative analysis of NSAIDs (ibuprofen, diclofenac) with a low limit of detection (0.1 ppm).
Conclusions:
- * The developed sensor array exhibits high accuracy in recognizing diverse analytes, including challenging aqueous anions.
- * The polymer environment plays a crucial role in enhancing the recognition capabilities of the fluorescent probe.
- * This approach offers a versatile platform for creating sensor arrays for various analytical applications, including difficult-to-detect species.
