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Quantification of Endothelial Fatty Acid Uptake using Fluorescent Fatty Acid Analogs
Published on: August 15, 2025
[Progress of studies in 20-hydroxyeicosatetraenoic acid on vascular endothelium]
1Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Peking University Health Science Center, Beijing 100191, China.
Abstract:
20-Hydroxyeicosatetraenoic acid (20-HETE) is an important metabolite of cytochrome P-450 pathway of arachidonic acid (AA). It has been demonstrated recently that 20-HETE played a significant role in physiology and pathophysiology process of vascular endothelium (EC). 20-HETE exerted oxidative stress and pro-inflammation effect through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system and nuclear factor-kappaB (NF-kappaB) pathway; it took part in the modulation of vascular dilation and constriction by mediating dissociation of endothelial nitric oxide synthase (eNOS) and inducing angiotensin converting enzyme in EC; it also promoted the proliferation of EC and angiogenesis. However, the domestic study about 20-HETE is rare. Therefore, the present paper reviewed the recent international studies of 20-HETE on EC.
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