Related Experiment Video
Updated: May 11, 2026

Identification of Post-translational Modifications of Plant Protein Complexes
Published on: February 22, 2014
RhoGTPases--NODes for effector-triggered immunity in animals
Lynda M Stuart1, Laurent Boyer
1Developmental Immunology and Center for Computational and Integrative Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA. lstuart@partners.org
Abstract:
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activation state of the RhoGTPases that are targeted by virulence effectors produced by pathogenic microbes. Interestingly, their findings reveal striking similarities with previous observations made in flies and plants, establishing the evolutionary conservation of this detection system in the innate immune arsenal in many taxa.
More Related Videos
11:21Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
Published on: March 12, 2015
08:25Unraveling Key Players of Humoral Immunity: Advanced and Optimized Lymphocyte Isolation Protocol from Murine Peyer's Patches
Published on: November 21, 2018
Related Concept Videos
Small GTPases - Ras and Rho
Three regulatory proteins control their activity:
Activation and Inactivation of G Proteins
Rab Proteins
Rab proteins switch between a cytosolic, GDP-bound inactive state and a membrane-anchored, GTP-bound active state. By themselves, Rabs show slow rates of GDP/GTP exchange and GTP hydrolysis. Thus, Rab proteins are considered...
Rab Cascades
The Ras Gene
Ras is a superfamily...
TGF - β Signaling Pathway