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Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...

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[Metabolic changes in pulmonary mitochondria of rats with experimental hyperhomocysteinemia].

Biomeditsinskaia khimiia·2017
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[Classification of local anesthesia methods].

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[The study of biochemical mechanisms of mitochondrial dysfunction in rats' hepatocytes during experimental hyperhomocysteinemia].

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[Aspiration in intraligamentous anesthesia].

D V Medvedev, A Zh Petrikas, M V Diubaĭlo

    Stomatologiia
    |May 30, 2013
    PubMed
    Summary

    Positive aspiration during intraligamentous anesthesia (ILA) in dental students is a strong indicator of effective pain relief. This study found that 94.4% of successful ILA cases showed positive aspiration, suggesting a vascular mechanism.

    Area of Science:

    • Dentistry
    • Anesthesiology
    • Pharmacology

    Context:

    • Intraligamentary anesthesia (ILA) is a dental injection technique.
    • Assessing the efficacy and safety of ILA is crucial for pain management.
    • The aspiration test (AT) is a standard safety measure in injections.

    Purpose:

    • To determine the frequency of positive aspiration during ILA.
    • To evaluate the depth of pulp anesthesia in the lower first molar (L6) using electrotesting.
    • To investigate the relationship between positive aspiration and effective anesthesia in ILA.

    Summary:

    • A prospective, randomized, crossover study involved 36 dental students receiving ILA with 4% articaine and epinephrine in L6.
    • Anesthesia was achieved in 114 injections (average 3.2 per molar), with electrotesting confirming pulpal analgesia.

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  • Positive aspiration occurred in 94.4% of successful ILA cases, correlating with effective anesthesia (100-200 mka).
  • Two cases (5.6%) achieved anesthesia with negative aspiration, indicating a potential variation in the mechanism.
  • Impact:

    • This study is the first to investigate the phenomenon of aspiration in ILA.
    • Positive aspiration appears to be a reliable indicator of effective intraligamentary anesthesia.
    • The findings suggest a vascular mechanism underlying the efficacy of ILA.