Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker proteins that...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy.

iScience·2026
Same author

Modeling respiratory viral infections and investigating immune responses: new advances in human organ chip models.

Biofabrication·2026
Same author

An AI-integrated organoid platform enables high-throughput functional evaluation of bioactive metal ions.

Bioactive materials·2026
Same author

Advancing mechanobiology from single molecules to complex cellular systems.

Nature nanotechnology·2026
Same author

Organ-on-a-chip toxicology.

Innovation (Cambridge (Mass.))·2026
Same author

Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems.

Advanced materials (Deerfield Beach, Fla.)·2026
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
Same journal

Sleep Disturbances and Male Reproductive Dysfunction: Pathophysiological Mechanisms Linking Obstructive Sleep Apnea and Sleep Deprivation.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Cell migration.

Xavier Trepat1, Zaozao Chen, Ken Jacobson

  • 1Institute for Bioengineering of Catalonia, Barcelona, Spain. xtrepat@ub.edu

Comprehensive Physiology
|May 31, 2013
PubMed
Summary
This summary is machine-generated.

Cell migration, involving single cells or groups, is crucial for development, immunity, and wound repair. Understanding cell movement aids in treating diseases like cancer and inflammation.

More Related Videos

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

Related Experiment Videos

Last Updated: May 11, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

Area of Science:

  • Cell biology
  • Developmental biology
  • Pathology

Background:

  • Cell migration is essential for multicellular organism organization, development, and homeostasis.
  • It plays roles in immune response, wound repair, and tissue maintenance.
  • Aberrant cell migration is linked to various pathologies, including cancer metastasis and inflammation.

Purpose of the Study:

  • To provide a comprehensive overview of cell migration.
  • To differentiate between single-cell and collective cell migration.
  • To highlight the significance of cell migration in biological processes and disease.

Main Methods:

  • Review of existing literature on cell migration.
  • Categorization of cell migration into single-cell and collective migration.
  • Discussion of the implications of cell migration in development and disease.

Main Results:

  • Cell migration is broadly categorized into single-cell and collective migration.
  • Single-cell migration is observed in leukocytes and fibroblasts.
  • Collective cell migration is prevalent in epithelial sheets during development and wound healing.

Conclusions:

  • Cell migration is a fundamental process with diverse roles in health and disease.
  • Understanding cell migration mechanisms is key to developing therapeutic strategies.
  • Further research into cell migration can lead to advancements in treating cancer, inflammatory diseases, and promoting wound healing.