Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Allergic Reactions: Anaphylaxis

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

Allergic Reactions

Allergic Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

Drug Toxicity: Allergic Reactions

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...

Hypersensitivities

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Match, The Workforce, The Future: The Key Role for Medical Educators.

Academic pediatrics·2025

Same author

This Encounter Isn't Over Yet: The Importance of Debriefing.

Pediatrics·2023

Same author

Food Selectivity, Rash, and Leg Pain in a 7-year-old Boy with Malnutrition.

Pediatrics in review·2023

Same author

National Pediatric Experience With Virtual Interviews: Lessons Learned and Future Recommendations.

Pediatrics·2021

Same author

Innovation to Dissemination Workshop: Selecting Outcome Measures to Translate Educational Innovations Into Scholarship.

MedEdPORTAL : the journal of teaching and learning resources·2019

Same author

Desquamating Rash in a Patient with Undiagnosed Netherton Syndrome.

The Journal of pediatrics·2017

Search research articles

Related Experiment Video

Updated: May 10, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis, urticaria, and angioedema.

Emily W Langley¹, Joseph Gigante

¹Allergy/Immunology, Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA.

Pediatrics in Review

|June 5, 2013

Summary

This article covers urticaria, angioedema, and anaphylaxis, detailing causes, symptoms, and treatments. It emphasizes recognizing anaphylaxis signs for rapid intervention and differentiating acute from chronic urticaria.

Area of Science:

Allergy and Immunology
Dermatology

Background:

Urticaria, angioedema, and anaphylaxis are common allergic reactions.
Accurate diagnosis and prompt management are crucial for patient outcomes.

Purpose of the Study:

To provide a comprehensive overview of urticaria, angioedema, and anaphylaxis.
To equip readers with knowledge for effective diagnosis and treatment.
To highlight key differences in managing acute versus chronic urticaria.

Main Methods:

Literature review of common etiologic agents.
Clinical guideline summary for anaphylaxis recognition and treatment.
Comparative analysis of acute and chronic urticaria evaluation and management strategies.
Discussion of papular urticaria causes.

More Related Videos

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Related Experiment Videos

Last Updated: May 10, 2026

Measuring Local Anaphylaxis in Mice

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Review of acute management protocols for stinging insect anaphylaxis.

Main Results:

Identification of common etiologic agents for urticaria, angioedema, and anaphylaxis.
Recognition of key signs and symptoms of anaphylaxis.
Distinction between acute and chronic urticaria, including diagnostic and therapeutic approaches.
Enumeration of causes for papular urticaria.
Outline of acute management for stinging insect anaphylaxis.

Conclusions:

Effective management of urticaria, angioedema, and anaphylaxis requires understanding their diverse etiologies and clinical presentations.
Rapid recognition and treatment of anaphylaxis are critical.
Differentiating acute and chronic urticaria guides appropriate patient care.